In the 1980's, Dr. Zasloff was Chief, Human Genetics Branch, National Institutes of Child Health and Human Development, at the National Institutes of Health. In 1988 Dr Zasloff founded Magainin Pharmaceuticals, Inc. a publicly traded biotechnology company. In the same year he joined the faculty of the University of Pennsylvania School of Medicine as the Charles E. H. Upham Professor of Pediatrics and Genetics, and assumed the position of Director of the Division of Human Genetics of the Children’s Hospital of Philadelphia. In July 1992 Dr. Zasloff left Penn and joined Magainin on a full time basis, and served as Executive Vice President and President of the Magainin Research Institute, a basic research division of the Company. From July 1996 through November 2000 Dr. Zasloff was Vice Chairman of the Board of Magainin Pharmaceuticals. In 2002, Dr. Zasloff was named Dean of Research and Translational Science at Georgetown, tasked with the integration of the basic science conducted at Georgetown with the clinical environment of the Medical Center. Since 2004, Dr. Zasloff has been actively engaged in studies of innate immunity within the Transplant Institute of the Department of Surgery.  Relevant publications are shown below:

 

1.  Zasloff, M. Magainins, "a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor"  Proc. Natl. Acad. Sci. 84: 5449-53, 1987.


2. Westerhoff, H.V., Juretic, D., Hendler, R.W., Zasloff, M. "Magainins and the disruption of membrane-linked free-energy transduction"  Proc. Natl. Acad. Sci. 86: 6597-601, 1989.

 

 

3. Moore, K., Wehrli, S., Rogers, M., Forrest, J.  McCrimmon, D., Zasloff, M. "Squalamine: a novel aminosterol antibiotic from the shark" Proc. Natl. Acad. Sci. 90:1354-1358, 1993.

 

4. Schonwetter, B.S., Stolzenberg, E.D., Zasloff, M.A. "Epithelial antibiotics induced at sites of inflammation"  Science 267:1645-1648, 1995.


5. Goldman, M.J., Anderson, G.M., Stolzenberg, E.D., Kari, U.P., Zasloff, M., and Wilson, J.M.  "Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis" Cell 88: 553-560, 1997.


7.  Stolzenberg, E.D., Anderson, G.M., Ackerman, M.R., Whitlock, R.H., and Zasloff, M.A. "Epithelial antibiotic induced in states of disease" Proc. Natl. Acad. Sci. 94: 8686-8690, 1997.

 

8. Sills, A.K., Williams, J.I., Tyler, B.M., Epstein, D.S., Davis, J.D., Sipos, E.P., McLane, M.P., Pitchford, S., Schonwetter, B., Gannon, F.H., Kinney, W.A., Chao, T.L., Donowitz, M., Laterra, J., Zasloff, M., and Brem, H. "Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature" Cancer Research 58: 2784-2792, 1998.

 

9. Rao, M., Shinnar, A.E., Chao, T.L., Feibush, B., Snyder, B., Sharkansky, I., Sarkhahian, A., Noecker, L.A., Zhang, X., Kinney, W.A. and Zasloff, M. "Aminosterols from the dogfish shark Squalus acanthias"  J. Nat. Prod. 63: 631-635, 2000.


10. Zasloff, M. "Antimicrobial peptides from multicellular organisms" Nature 415: 389-395, 2002.

 

11.  Zasloff, M. "Defending the epithelium"  Nature Medicine 12: 607-608, 2006.


12. Lipsky, B.A., Holroyd, K.J. and Zasloff, M. "Topical versus systemic antimicrobial therapy for treating infected diabetic foot ulcers: a randomized, controlled, double-blinded multicenter trial of pexiganan cream" Clin Infect Dis 47: 1537-45, 2008.

 

 

 

 

 



 

Michael A. Zasloff, m.d. Ph.D.